| Pair Name | Alpha-Hederin, Paclitaxel | ||
| Phytochemical Name | Alpha-Hederin (PubChem CID: 73296 ) | ||
| Anticancer drug Name | Paclitaxel (PubChem CID: 36314 ) | ||
| Structure of Phytochemical |
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| Structure of Anticancer Drug |
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| Pair Name | Alpha-Hederin, Paclitaxel | |||
| Disease Info | [ICD-11: 2C25] | Lung cancer | Investigative | |
| Biological Phenomena | Induction-->Autophagy | |||
| Gene Regulation | Up-regulation | Cleavage | CASP3 | hsa836 |
| Up-regulation | Cleavage | PARP1 | hsa142 | |
| Up-regulation | Expression | ROS1 | hsa6098 | |
| Up-regulation | Expression | SQSTM1 | hsa8878 | |
| In Vitro Model | NCI-H1299 | Lung large cell carcinoma | Homo sapiens (Human) | CVCL_0060 |
| NCI-H1650 | Minimally invasive lung adenocarcinoma | Homo sapiens (Human) | CVCL_1483 | |
| Result | Our findings suggest that α-Hed can increase the killing effect of Tax on NSCLC cells by promoting ROS accumulation, and that combining α-Hed with classical Tax represents a novel strategy for treating NSCLC. | |||
| No. | Title | Href |
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| 1 | The Novel Autophagy Inhibitor Alpha-Hederin Promoted Paclitaxel Cytotoxicity by Increasing Reactive Oxygen Species Accumulation in Non-Small Cell Lung Cancer Cells. Int J Mol Sci. 2018 Oct 18;19(10):3221. doi: 10.3390/ijms19103221. | Click |
